In our department we started using molecular biology techniques from the late 80s. Initially we worked with in situ hybridization with DNA probes biopsies with enzymatic labeling, currently only performed in situ hybridization to detect Epstein-Barr virus by PNA probes. In 1989 we added to our laboratory, using materials purchased with a grant DGCYT, hybridization techniques with radioactive probes with which we began conducting a systematic typing of different human papilloma virus. (more...)