One ion channel that models the thermal hyperalgesia induced by proinflammatory factors is the integrator of pain ion channel TRPV1 (transient receptor potential vanilla type I). The TRPV1 is a calcium-permeable channel which can be activated by capsaicin, acid pH extracellular and temperatures above 43 º C, which is located on the peripheral terminals of nociceptors, where the detector harmful levels of heat. (more...)