The yeast MAP kinase Hog1 coordinates the transcriptional program required for cell survival upon osmotic stress, although the mechanisms by which these kinesis regulate gene expression are not clearly defined. The group at the Universitat Pompeu Fabra led by Francesc Posas had already described two different control mechanisms of gene expression by MAP kinesis: direct modification of transcription factors and direct recruitment to specific promoters by the MAP kinase RNA complex Polii. In this new work shows that the MAP kinase Hog1 induces gene expression in response to stress, through a mechanism involving recruitment of the complex of the his tone deacetylase Rpd3-Sin3 to promoters of genes regulated by osmotic stress. (more...)