In the Faculty of Medicine of the University of Valladolid, the group of eicosanoids studied the role of iPLA2 (phospholipase A2 calcioindependiente) in group VI in the process of incorporation and release of arachidonic acid from phospholipids and, ultimately, in the apoptosis. The PLA2 family is involved in the hydrolysis of arachidonic acid (AA) from phospholipids (PL). The iPLA2 involved in the incorporation of AA in the PL, ensuring the availability of intermediate acceptors. It is worth noting the role of these reactions in the cell life, as in resting cells prevail incorporation of arachidonic pathways on release, while cells stimulated the dominant reaction is the deacylation. (more...)