Metalloproteinase's, enzymes involved in the process of hydrolysis and digestion of proteins, play vital roles in physiological processes and diseases such as Alzheimer's disease, arthritis, osteoporosis and cancer. We have seen one of these metalloproteinase's, the hCPA4 (human carboxypeptidase's A4), is over expressed in some tumor cell lines. A team of researchers from the CSIC and the Autonomous University of Barcelona have solved the atomic structure of this enzyme complex formed and Latex in, the only known endogenous inhibitor of Metallocarboxypeptidases. (more...)