Posts Tagged ‘DNA’

Biochemistry as a science, is making a trip from physiological conditions to extreme testing environments, in which the behavioral rules derived from the study of hydrated systems may not be valid. One example is DNA chips, popular in genomic studies, based on the assumption (not proven) that the structure of DNA and pattern recognition are equal when the molecule is Now Go in aqueous solution or bound to a cationic membrane . Proteomics, an emerging area of research revolves around the use of mass spectroscopy apparatus, in which the macromolecules are injected into the gas phase at high pressures and temperatures.

Read the rest of this entry »

The bacterial conjugation, the main route for horizontal gene transfer to prokaryotes, is a quick way for the evolution of bacterial genomes leading to organisms with new ecological or pathogenic characteristics. The acquisition of antibiotic resistance by pathogens is related to the conjugal transfer of mobile genetic elements. The transfer of genes between kingdoms, from bacteria to plants and fungi, are special cases of conjugation and even in cell division and sporulation, there are similar mechanisms for transfer.

Read the rest of this entry »

The cover image of the international edition of the February 13 issue of the journal Angewandte Chemie German represents a new form of DNA helices formed by three researchers who have described CSIC, Institute of Biomedical Research of the PCB and the University of Birmingham, in a collaboration that has found a surprising structure almost by chance, while trying to test the effectiveness of a drug as a therapeutic agent against DNA targets. Read the rest of this entry »

The genetic model of cancer has led research in this field for decades, until Feinberg and Vogelstein (Johns Hopkins) described in 1983 an extensive loss of DNA methylation in tumor cells. With the results came the first evidence that epigenetic changes, heritable but outside the sequence, could make the cancer. The manifest skepticism that greeted the idea was in part due to the slow pace of progress in this field over the next fifteen years. Read the rest of this entry »

Cancer is a genetic disease and epigenetics. The first thing is have ample evidence for years. Of the latter being generated every day more conclusive evidence. Demonstrate it has cost, despite the intense research carried out in this field and know the common feature in cancer cells provides the inactivation of tumor suppressor genes by mechanisms such as changes in the patterns of methylation of histones and DNA. Read the rest of this entry »

Cancer, such as biological process that goes beyond the laws of development and cellular growth, requires relocation process and investigate molecular mechanisms that lead to uncontrolled cell division, genomic instability and tumor development. The identification of these new patterns of growth and development can be very important to understand and combat processes tumorogénesis.1 It appears from research such as referenced here, the Cdc6 and other cellular components are joined, forming complexes prerreplicativos before initiated DNA duplication. Read the rest of this entry »

All processes of gene activity are accompanied by alterations in DNA helical tension. Consequently, the double helix twists on itself, or supercoiled to remain stable throughout its length. This tension may be very high during the processes of transcription and DNA replication, since the two strands, always linked in the double helix, are forced to separate, in part or total. Due to the enormous length and the large condensation of DNA molecules in chromosomes, the coil voltage can not dissipate spontaneously. Read the rest of this entry »

The transition between each of the phases of the cell cycle is controlled by phosphorylation processes carried out by enzymes known as cyclin dependent kinase (CDK). In mammalian cells, the enzyme bound to CDK2 cyclin A acts as the main promoter of the transition from G1 to S phase cell cycle progression and S phase, when DNA replication. Thus, the cyclin A-CDK2 complex binds to a large number of regulatory proteins at different times during cell cycle progression. Read the rest of this entry »