Colorectal cancer is a leading cause of cancer death worldwide. Most of these tumors as benign lesions, but a small proportion may progress to malignant stages to accumulate genetic alterations in oncogenes and tumor suppressor genes. It is estimated that between 30 and 50% of people over age 60 may develop these benign adenomas. Colorectal cancer is in first position of the record of most common cancers in Spain and causes more than half a million deaths each year worldwide. The team's work Batlle on tumor initiation and progression of it, from the early stages until the formation of aggressive tumors, has discovered and examined cellular and animal experimental models that mimic this devastating disease, with