Protein Expression & Sequence Database

LifeProt™ database contains protein expression and sequence information for a variety of human tissues, with links to related gene information in LifeSeq® database. Read the rest of this entry »

Microarray Analysis and Data Management

GEMTools™ software provides powerful tools for managing and analyzing the results of GEM™ microarray experiments. It utilizes a proprietary image recognition algorithm which interprets the scanned images of a processed GEM array. GEMTools software then compares those results against a library database to identify which genes were differentially expressed in the two cell samples and at what intensity. Read the rest of this entry »

Annotation : A functional description of a clone, which may include identifying attributes such as locus name, keywords, and Medline references.

BAC : Bacterial Artificial Chromosome; see cloning vector.

BLAST  : The Basic Local Alignment Search Tool is a fast technique for detecting ungapped subsequences that match a given query sequence.

BLIMPS : The BLocks IMProved Searcher is a search tool used to compare a DNA sequence against protein patterns in the Blocks database. Read the rest of this entry »

Making DNA Probes From Cell Samples

First, the messenger RNA (mRNA) is extracted from the normal or unaffected cell sample, and a fluorescent-labeled cDNA probe is generated. The probe represents all of the genes expressed in these reference cells. Read the rest of this entry »

GEM Library

Building a GEM array begins with the creation of a GEM library, a collection of complementary DNA (cDNA) molecules that contain genetic information from the biological system of interest.
Arraying cDNA on Glass Chips

First, individual cDNA molecules are isolated into unique pools and amplified. Next, a micro-sample (containing about one-millionth the volume of a drop of water) of each cDNA is deposited on a glass surface in an array format with each gene occupying a unique location. The micro-samples are then chemically bonded to the glass. Read the rest of this entry »

Fabricate Custom GEM arrays from provided cDNA clones. Database partners can also choose from  proprietary clone libraries.

Once the Custom GEM array is built, you provide two samples per GEM for processing. We generate fluorescent labeled cDNA probes, hybridize them to the GEM arrays, scan the arrays, analyze the images, and provide complete data on gene expression. Data can be delivered in a standard format or in GEMTools software for further analysis and reporting. Read the rest of this entry »

Incyte-Proprietary Clones on Microarrays

Incyte has combined its in-house bioinformatics expertise and unparalleled genomic databases to develop several new prefabricated microarrays. Each contains up to 10,000 sequence-verified, Incyte-proprietary clones represented in our LifeSeq, ZooSeq, and PathoSeq databases and in our GeneAlbum reagent set. Read the rest of this entry »

Microarray Data Management & Analysis

LifeArray™ software manages and analyzes data resulting from microarray hybridization experiments. It includes a searchable database which can be loaded with microarray experimental results from a variety of formats. Read the rest of this entry »

This new Incyte program will focus on identifying the role of genetic diversity in disease and drug response by developing technologies and programs for the pharmaceutical industry in polymorphism discovery, genotyping and pharmacogenetics.

The Future of Drug Development

Understanding the key genetic differences between individuals will enable pharmaceutical researchers to create better therapeutics. Improved therapeutics can reach new levels by being able to differentiate between individuals according their predisposition to disease processes or susceptibility to adverse effects of medications. Read the rest of this entry »

Chromosome 7 accounts for approximately 5% of the human genome. It is estimated to be 136 centiMorgans (cM) in length and contains 170 million basepairs (170 Mb) of DNA. We are mapping and sequencing two targets along chromosome-7, one at 7q31.3, and the other at 7p14. Both are targets with little prior characterization other than the STS map, and as such, are representative of the bulk of the human genome. Read the rest of this entry »