Microtubules (MT) can nuclear membranes of the Golgi apparatus (GA). This nucleation requires γ-tubulin complex and γ-Turkish War (γ-tubulin ring complex), a protein recruited by the GA through interactions with proteins GMAP210 and AKAP450. However, microtubules nucleated at the Golgi different from those of the centrosome that are arranged symmetrically, have a preferred growth towards the end of the cell migration and also to be easily acetylated are more stable and are coated with protein-CLASP 2.

The peripheral protein AKAP450 enlists the GM130, which in turn binds to a g-Turkish, giving a capacity of nucleation cis-Golgi compartment. Therefore, the AKAP450, a protein localized in both the centrosome and in GA, acts as a general regulator

of MT nucleation cell. The study by Rivero et al., Department of Cellular Signaling CABIMER-CSIC, Seville, explains the functional differences between GA and microtubules of the centrosome in regard to polarization and cell migration. Those cells lacking the AKAP450 in GA, but not in the centrosome, can not migrate, however, retain the ability to reorient its centrosome and Golgi membranes to the end of the cell.

It appears that the microtubules nucleated in GA have specific effects on cell migration, this being independent of the centrosome and Golgi cell positioning motor. However, the direct role of AKAP450 in migration and cell polarization through a mechanism independent of microtubules can not be excluded. Further studies will determine how the microtubules nucleated in the GA control this cell migration and whether they can regulate other cellular processes.

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