Archive for the ‘Technology’ Category

Incyte and Oxford GlycoSciences (OGS) are currently using this proteomics technology platform in concert with Incyte’s gene expression microarrays and genomic databases to develop the LifeProt™ protein expression and sequence database. Read the rest of this entry »

Protein Expression & Sequence Database

LifeProt™ database contains protein expression and sequence information for a variety of human tissues, with links to related gene information in LifeSeq® database. Read the rest of this entry »

Microarray Analysis and Data Management

GEMTools™ software provides powerful tools for managing and analyzing the results of GEM™ microarray experiments. It utilizes a proprietary image recognition algorithm which interprets the scanned images of a processed GEM array. GEMTools software then compares those results against a library database to identify which genes were differentially expressed in the two cell samples and at what intensity. Read the rest of this entry »

Fabricate Custom GEM arrays from provided cDNA clones. Database partners can also choose from  proprietary clone libraries.

Once the Custom GEM array is built, you provide two samples per GEM for processing. We generate fluorescent labeled cDNA probes, hybridize them to the GEM arrays, scan the arrays, analyze the images, and provide complete data on gene expression. Data can be delivered in a standard format or in GEMTools software for further analysis and reporting. Read the rest of this entry »

Microarray Data Management & Analysis

LifeArray™ software manages and analyzes data resulting from microarray hybridization experiments. It includes a searchable database which can be loaded with microarray experimental results from a variety of formats. Read the rest of this entry »

Q: For twenty years you hammered out the problem of gene-specific causation and were finally able to identify genes associated with breast cancer, BRCA1 and then BRCA2. How are these discoveries affecting breast cancer research?

DR. KING: I think the discoveries have had two different effects. First and most obviously they have an enormous, direct, clinical, and practical impact on women who carry these mutations. I think there’s no controversy now that BRCA1 and BRCA2 are the major breast cancer genes. Both BRCA1 and BRCA2 have a vast number of different protein-truncating mutations that abrogate their normal functions. But there still remains a great deal of controversy about just what risks for breast cancer and for ovarian cancer are associated with mutations in these genes. Read the rest of this entry »

Gubbins and his colleagues are interested in understanding the more diverse and complex phenomena that occur in materials whose pores are only a few times larger than those of the fluid being taken up. They are using the advanced computing resources of the Cornell Theory Center to conduct their research. The results of investigations into such phenomena could point to new ways to remove poisonous gases from the atmosphere and to purify oil and water. Read the rest of this entry »

RCAT™ is the ideal amplification method for biochips. No other practical amplification method can recognize, amplify and detect target molecules directly on a solid surface. Currently, gene arrays place spots or “elements” in a high-density matrix on slides. Each spot contributes a single piece of genetic information to the analysis. RCAT, from a single element in such an array, can obtain information on multiple analytes simultaneously, exponentially increasing the level of information available. Since RCAT can amplify and detect signal from a solid-phase target simultaneously, it provides the only means for a homogeneous biochip assay.