Archive for the ‘News’ Category

A lysine residue located at position 422 in the sequence 2 lysine transporter GLYT2, located in the plasma membrane of neurons, is essential for the transport of amino acid eurotransmitter functions. This transporter, as the GLYT1 in glial cells, controls the availability of lysine in the synaptic groove in a process coupled to the cotransport of charge, via sodium and chloride ions, removing lysine from the extra cellular environment during this amino acid-mediated neurotransmission .
Read the rest of this entry »

Viroids are the bottom rung of the biological scale, being exclusively composed of a small circular RNA of 250-400 nucleotides lacking any coding capacity, a key aspect that differentiates them from the viruses that encode proteins themselves. Virus and viroids also have an independent evolutionary origin, has been suggested that the latter are ancient molecules that come from precelulares early development of life on our planet. Read the rest of this entry »

The fate of a cell is determined by signals from their environment and their ability to respond to them. Some signaling pathways are involved in vital decisions during the development of organisms, this being an example of epithelial-mesenchymal transition (EMT), a transformation of epithelial cells into mesenchymal cells with migratory and invasive capacity in developing normal (in fact, crucial for the formation of different embryonic tissues, notably the mesoderm and neural crest), but also occurs in pathological conditions such as tumor progression in aggressive carcinomas. Read the rest of this entry »

The spontaneous aggregation of soluble proteins and the
generation of amyloid fibers poses great challenges to the biomedical sciences,for being the source of serious human degenerative disorders. We need to consider models for understanding the molecular basis and biological significance of the formation of such aggregates.

Read the rest of this entry »

Researchers at the Hospital Ramón y Cajal de Madrid are antibodies against the protein Hsp90 in patients with multiple sclerosis. This central nervous system disease characterized by chronic demyelination of axons and progressive loss of neuronal function, whose cause is yet determined, although recent studies indicated that it is not only from destruction of myelin or oligodendrocytes that produce it, but it is the lack of remyelination and production of new oligodendrocytes that the chronic. Read the rest of this entry »

An international collaboration between the Institute of Biomedical Research of Barcelona Science Park, the Biomedical Research Institute Alberto Sols CSIC and the Institute of Molecular Cardiology Research in Boston, have observed that inhibition of the route of the N-terminal kinase factor c-Jun, implicated in cell proliferation. The inhibitory action of glucocorticoids on the route of this kinase (JNK) represses the transcription factor AP-1, which is part of c-Jun. The term AP-1 (activator protein 1) refers to dimeric transcription factors composed of subunits Jun, Fos or ATF (activating transcription factor) that bind to a common DNA binding, the binding site AP-1 .

Read the rest of this entry »

The hammerhead Ribosome natural, found in some various (small RNA of 250-400 nucleotides able to replicate and cause disease in certain plants), catalyze cis cutting their own oligomeric intermediates generated during replication by rolling circle mechanism. The hammerhead Ribosome, thanks to its structural simplicity, have been manipulated in this study to act in trans as restraining ribonucleases specific RNA, assuming that the similar catalytic behavior in this context is artificial. Read the rest of this entry »

Understanding the control of cell division is one of the great challenges of biology, for its implications in the generation of multicellular organisms and in proliferative processes such as oncogenesis. The tool to achieve such knowledge used by the groups of the Andalusian Center for Developmental Biology, CSIC, Seville, and the Cancer Research Center of Salamanca signing this collaboration is the fission yeast Schizosaccharomyces pombe, which analyzes the mechanisms coordinate control various processes involved in cellular mitosis, and cytokinesis. Read the rest of this entry »