Archive for the ‘News’ Category

El pasado 10 de noviembre se presentó en la sede central del CSIC en Madrid el nuevo portal de internet de la Sociedad Española de Bioquímica y Biología Molecular. El acto, que se enmarcaba dentro de las actividades programadas con motivo de la Semana de la Ciencia 2009, estuvo presidido por M. Pilar Tigeras, vicepresidenta adjunta de Organización y Cultura Científica del CSIC, y por Miguel Ángel de la Rosa, presidente dela SEBBM. Read the rest of this entry »

Advances in recent decades have revealed the genetic scenario of the formation of melanoma including mutations and signaling pathways. Researchers at the Melanoma Group, headed by Dr. Soengas in the National Cancer Research Center (CNIO), have made human melanoma cells to destroy themselves to activate simultaneously two programs of cell death: apoptosis and autophagy. This research opens a new avenue for the development of new treatments against this disease. Read the rest of this entry »

Diseases of Charcot-Marie-Tooth (CMT) are a heterogeneous group of inherited neuropathies. The molecular mechanisms leading to the CMT are as varied as their genetic and related genes are translated by a wide variety of proteins with roles in central nervous system cells. Read the rest of this entry »

One ion channel that models the thermal hyperalgesia induced by proinflammatory factors is the integrator of pain ion channel TRPV1 (transient receptor potential vanilla type I). The TRPV1 is a calcium-permeable channel which can be activated by capsaicin, acid pH extracellular and temperatures above 43 º C, which is located on the peripheral terminals of nociceptors, where the detector harmful levels of heat. Read the rest of this entry »

The Ras superfamily of GTPases regulate important cellular processes like cell proliferation, differentiation and cell survival, mutations involving the development of cancer. In cancer, apart from the Ras proteins (H-Ras, N-Ras and K-Ras) are also implicated other proteins such as TC21, which shares most of the Ras effectors. TC21 protein may be farnesyl and geranyl, while Ras farnesyl just are. Read the rest of this entry »

In recent years trying to decipher the mechanisms of circadian clock function. Genetic and molecular research on Arabidopsis thaliana were used to identify components of the clock and regulatory mechanisms in the circadian oscillator. Initially proposed a reciprocal regulation between transcription factors CCA1 (circadian clock associated) and LHY (late elongated hypocotyl) with the regulator TOC1 (timing of cab expression 1). Read the rest of this entry »

Fanconi Anemia is a common disease hereditary syndromes group of bone marrow failure. The induced pluripotent stem (iPS: Induced pluripotent stem cells) can be obtained in vitro from skin fibroblasts and from other somatic cell division, introducing specific genes or gene products that reprogram the somatic cell nucleus matures. The most common protocols used viral vectors to transfer four specific genes (Oct4, Sox2, Klf4 and c-MYC). Similar to embryonic cells, iPS cells can grow indefinitely in the laboratory and have the ability in vitro to differentiate into several cell lines, including hematopoietic line. Read the rest of this entry »

Juan Carlos Izpisúa Belmonte, PhD in Biochemistry and Pharmacology from the Universities of Bologna and Valencia, has postdoctoral at the University of Marburg and the European Molecular Biology Laboratories (EMBL) in Heidelberg. Since 1993 works in the Gene Expression Laboratory at the Salk Institute in California and runs a prestigious center for work performed with the zebrafish animal model. Read the rest of this entry »