Archive for the ‘Bioscience’ Category

An online atlas and database of the Drosophilia Nervous System. Implementation of the pilot version of Flybrain, from the University of Arizona, supported by an SGR Grant from the National Science Foundation and a postgraduate studentship to Douglas Armstrong from the UK Biotechnology and Biological Sciences Research Council.

A database on Drosophila brain and neural mutants developed by Prof. Karl Fischbach at the University of Freiburg, Germany. Current funds supporting the Flybrain database are from the US National Science Foundation  and a grant from the Deutsche Forschungsgemeinschaft

Title: Primer on Molecular Genetics
Creator: Human Genome Management Information System, U.S. Department of Energy (DOE), Oak Ridge National Laboratory
Provider: William H.Welch Medical Library, The Johns Hopkins University

Description: The Primer on Molecular Genetics is an introduction to the science behind the human genome project and was prepared for the Department of Energy’s (DOE) Human Genome Program Report for 1991-92 . This document contains information on the Biology of DNA, techniques for Sequencing and Mapping Genes, and Genome Informatics. Figures are included. It is currently under revision. There are two versions available, an Adobe Acrobat version (which allows users to print originals) and a html version.

The XXVII Congress of the SEBBM (Lleida, September 2004), authors who have signed this collaboration between universities in the Basque Country and Victoria (Canada) presented his studies on the interaction of nucleoplasmin with chromatin early somatic after fertilization of the oocyte. Nucleoplasmin, first described as a molecular chaperone protein (for RA Lackey in 1978) is an acidic protein of the oocytes whose activity is regulated by phosphorylation.  Read the rest of this entry »

Most sporadic colorectal cancers are initiated by activating mutations in the route Want (wingless type), whose products are implicated Eph receptors (Ephraim’s) and its ligands.A study on the development of colorectal cancer sample, for the first time that the activity of Eph receptors (responsible for controlling the structure of intestinal epithelium through repulsive interactions with their legends) cancels the progression of benign to malignant tumors. Read the rest of this entry »

The action of neurotrophins, factors that modulate the differentiation, maturation and neuronal regeneration, and even death of neurons, is carried out through specific receptors. Among them, the Trk A tyrosine kinase with activity. After activation, these receptors give rise to an intracellular signaling cascade, which culminates with the expression of certain genes.

So far, these receptors were found only in vertebrates, and the search had been barren of invertebrates, made in the two most widely used models, Drosophila melanogaster and Caenorhabditis elegans, as their appearance was related to the evolution of early vertebrates. However, a paper published in Development, in collaboration between the universities of Barcelona and Lleida, has identified the Trk receptor gene in the genome of Branchiostoma floridae, an amphioxus genome equipped with a pre-archetypal gene duplication arose during the evolution of vertebrates. Read the rest of this entry »

Three papers were signed at a joint CSIC and the University of Salamanca describe the identification and characterization of a new family of serine-threonine kinases of human carcinoma, in the course of evolution, separated from the branch that subsequently caused the casein kinases. The catalytic domain of this new family VRK (vaccinia-related kinases) is related to the vaccinia virus B1R protein.  Read the rest of this entry »

Metalloproteinase’s, enzymes involved in the process of hydrolysis and digestion of proteins, play vital roles in physiological processes and diseases such as Alzheimer’s disease, arthritis, osteoporosis and cancer. We have seen one of these metalloproteinase’s, the hCPA4 (human carboxypeptidase’s A4), is over expressed in some tumor cell lines. A team of researchers from the CSIC and the Autonomous University of Barcelona have solved the atomic structure of this enzyme complex formed and Latex in, the only known endogenous inhibitor of Metallocarboxypeptidases. Read the rest of this entry »

Aware of the importance of electrostatic and hydrophobic interactions in the formation of complexes that allow an efficient electron transfer between
molecules, such as the ferredoxin NADP + reeducates (FNR) and ferredoxin (Fd). The FNR catalyzes the transfer of electrons sequentially from two molecules of Fd to NADP + molecule in order to store energy in the form of reducing power NADPH.

We have seen that certain residues in the FNR are also critical for interaction with flavodoxin (Fled), redo protein binding of flaying mononucleotide, though,
so far, has not found any clue to her that waste may be associated with side
chains of FNR.
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