Archive for the ‘Bioscience’ Category

The p53 tumor suppressor gene regulates the expression of p53-induced genes (PIG: p53 induced genes) that initiate apoptosis. The PIG3 or TP53I3 is the only member of the superfamily of dehydrogenases / reductases medium chain induced p53 proapoptotic be used as a marker. Although it is well known PIG3 participation in the apoptotic pathway or protein or its mechanism of action have been well characterized. Read the rest of this entry »

The mitochondrial protein BCL-2 family are critical in apoptosis. They are structurally related and can be classified as a functional and structural. Can be subdivided into multidomain proapoptotic proteins (such as BAX and BAK), multidomain antiapoptotic proteins (such as BCL-2), and BH3-only proteins (such as BID or BIM). All these lead to the regulated permeability of the mitochondrial outer membrane with release of cytochrome c and activation of effector caspases. They may also have other functions in other subcellular compartments. Read the rest of this entry »

The gene TARBP2 (TAR-RNA binding protein 2) is key to the production machinery of microRNA. These microRNAs are short strands of ribonucleic acid that regulate the intensity of the activity of other genes activated and deactivated, and active oncosupresora has been demonstrated in the past. In this study, conducted by a group of scientists from Finland, Portugal, USA and Spain, led by Manel Esteller, who led the group in the Cancer Epigenetics CNIO in Madrid and currently leads the Epigenetics of IDIBELL in Barcelona, have examined a number of cell lines of colorectal cancer, Read the rest of this entry »

The cell cycle progression is governed by a family of kinases (cdk: cyclin dependent kinases) whose activities are regulated by binding to regulatory subunits called cyclins. During the cell cycle and activate form specific pairs of cdk and cyclins. The pair CDK1 with cyclins A and B governs the transition G 2 / M. During the cell cycle cdk levels remain relatively constant and the cyclins fluctuate, thus activating specific cdk. Read the rest of this entry »

Microtubules (MT) can nuclear membranes of the Golgi apparatus (GA). This nucleation requires γ-tubulin complex and γ-Turkish War (γ-tubulin ring complex), a protein recruited by the GA through interactions with proteins GMAP210 and AKAP450. However, microtubules nucleated at the Golgi different from those of the centrosome that are arranged symmetrically, have a preferred growth towards the end of the cell migration and also to be easily acetylated are more stable and are coated with protein-CLASP 2. Read the rest of this entry »

The hemidesmosomes are multifunctional multiprotein complex of great importance to the integrity of epithelia. Exercise of mediators of cell adhesion and confer resistance to mechanical stress, linking the extracellular matrix with cytokeratin filaments in the cell. They consist of three components transmembrane: α6β4 integrin, BP180-type collagen XVII and integrin-associated tetraspanina CD151. Integrin α6β4 is a receptor for laminin with high specificity for laminin-5, or basal membrane protein that binds to epidermal cytokeratin through plectina and BP230. Read the rest of this entry »

Joan Massagué doctorate in pharmacy at the University of Barcelona (UB) and obtained a postdoctoral fellowship at Brown University. In 1989 he joined the cell biology program at Memorial Sloan Kettering Cancer Center, New York, and in 2003 acceded to the direction of Biology and Cancer Genetics. Read the rest of this entry »

The enzyme DNA ligase is essential for DNA replication, recombination and for repair of genetic material in vivo. From virus and both prokaryotic and eukaryotic organisms have been isolated and characterized different DNA ligases, most recently, have been cloned and purified DNA ligases from thermophilic microorganisms. The ligases characterized to date consist of a single polypeptide chain and exhibit different activities. The ligation activity includes: 1) the binding of double-stranded nucleic acids with cohesive terminals, 2) the joining of blunt-end complex, and 3) the binding of nucleic acid fragments through gap sealing mechanism (nick -sealing). Read the rest of this entry »