Archive for the ‘Bioscience’ Category
Methods for DNA sequencing
August 30th, 2009
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Liquid gold organisms
Not many people get organic substances in pure form (or in the form of homogeneous mixtures) are already in antiquity. Fats and oils, no doubt, are among their number. Therefore, their names are in all languages simple native, although the chemists call them also lipids (from the Greek "liposome" - fat). To detect them was easy because they occur in all living organisms, and often in large numbers. Nature took care of animals and plants, providing them with supplies of fuel for cold and hungry days. Animals put this fuel, mainly around the internal organs and under the skin to fat deposits at the same time served as a shock-absorbing cushion shocks and heat insulator. OtherRCAT™—Biochips
RCAT™ is the ideal amplification method for biochips. No other practical amplification method can recognize, amplify and detect target molecules directly on a solid surface. Currently, gene arrays place spots or “elements” in a high-density matrix on slides. Each spot contributes a single piece of genetic information to the analysis. RCAT, from a single element in such an array, can obtain information on multiple analytes simultaneously, exponentially increasing the level of information available. Since RCAT can amplify and detect signal from a solid-phase target simultaneously, it provides the only means for a homogeneous biochip assay.
Tags: The First Effective Whole Genome Amplification
Unlimited DNA from a few cells.
The
growing trend to study disease and drug response at the molecular level
has focused attention on DNA as a precious resource. Multiple Displacement
Amplification (MDA) technology developed by MSI enables the first effective
whole genome amplification method. The MDA method is a quantum leap over
other currently available whole genome amplification methods, which are
based on PCR
The MSI MDA method rapidly amplifies the genome with comprehensive loci
coverage and minimal bias between any loci, yielding 10+kb fragments in
a simple, scalable reaction.
Proteomics
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Technology Transforming Bioscience
A strong demand has emerged in the life science industry for enabling technologies that can generate, analyze, and interpret genomics and proteomics data much more quickly and cost effectively than currently possible otherwise. Molecular Staging Inc. (MSI), a life sciences company, is addressing this demand with a portfolio of products and services based on technologies that are transforming the detection and measurement of both proteins and nucleic acids.
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RCATTM For Cells and Tissues
Immunohistochemistry (IHC) and flow cytometry are highly respected technologies
for the diagnosis of cancer and infectious disease. They are widely used
by pathologists and increasingly used by large pharmaceutical and biotechnology
companies to assist in target validation and the discovery of new drugs.
RCATTM on Beads
Microspheres, also known as latex beads, polystyrene beads, and microbeads
are a proven solid-phase format for development of assays used in both research
and clinical diagnostics.
Key advantages to bead format assays are:
- Ease of manufacture
- Faster assays; near–fluid-phase binding kinetics
- Increased sensitivity; increased surface allows more antigen, antibody,
or DNA to be included in the assay - Easily automated assay formats